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5.3 Effects of microbial metabolites on bloodbrain barrier structure and function Metabolites derived from gut microbiota not only regulate inflammatory responses but also directly affect the reconstruction and stability of the BBB (193)

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Contact your GP within 2448 hours if headaches progressively worsen despite simple painkillers, persist beyond 48 weeks of stable dosing, or significantly interfere with daily activities

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A complete ligament tear, advanced boneonbone arthritis, or severe joint deformity often still requires orthopedic evaluation and, in some cases, surgery